User blog comment:Matthew Paul/BioWare never made a case?/@comment-3046679-20130110160425/@comment-24174486-20130113214630

There's several parallels between the genophage and the Reaper cycles. Both cull the population of a group (krogan, organic life) in an attempt to prevent its extinction. Both have various scenes based on your choices that contribute to it not necessarily being a black-and-white issue (who's leading the krogan, the possibility of the quarians being wiped out). Both have a major character who contributed to them deciding to turn against what they did (Mordin Solus, the Catalyst).