User blog comment:Señor action/mass effect 4 and beyond/@comment-5161018-20120630035723/@comment-4950455-20120630044936

There's some very serious reasons why a sequel would be both nigh-impossible and simply undesirable, but I'm not going to rehash those again.

I will say, though, that I think you're misreading the situation with Cerberus. It's not TIM's death that finished it off, or even the strike on Cronos Station - it's the fact that they implanted themselves to a man with Reaper technology. It's safe to say that pretty much all of Cerberus is indoctrinated by the end of ME3; while it's not clear what happens to the indoctrinated after the Reapers are defeated, there's never been any reason to suggest that they can recover.

So given that, I'd say Cerberus is pretty thoroughly dead. There might be a few non-indoctrinated survivors, but the post-game environment isn't likely one that they can rebuild in, given how thoroughly both their organization and its pro-human message have been discredited by the events of the war.