User blog comment:DeadpoolN7/Mass Effect 4/@comment-4941068-20121016191112/@comment-118213-20121017011950

Almost certainly the protagonist would be human, or atleast include the option of being human. I'd also imagine it taking place in the decades/centuries following the Reaper invasion, or in the years prior. I think it's very unlikely they are going to go back so far to a point where humanity doesn't even exist.

I'd imagine the relation between the two wouldn't be dissimilar to Dragon Age Origins and Dragon Age II, ie both seperate protagonists meet a character (Flemeth) at around the same point, and there stories go two completely different ways. The main protagonist, IF there is a ME4 almost certainly will NOT be Commander Shepard.