User blog comment:James12708/Bioware Hasn't written themselves into a corner/@comment-4950455-20121109062047/@comment-24174486-20121109171417

"Synthesis alone would be a monumental task; they would have to reskin every organic lifeform in the game to have green circuitry and glowing eyes... or whatever."

Granted, I don't know much about programming games, but having two different skins for characters doesn't actually sound too difficult. All they would need are two models for different characters—not-Synthesis and Synthesis—and a flag which tells the game which models to use. I think Destroy and the lack of synthetic life (or, depending on how far after the series the game is set, the lack of past synthetic life such as the geth) would be harder to tackle, but BioWare is BioWare and I doubt anyone else could do it as well as they could.

"Now, I don't want to sound harsh, but BioWare has had trouble when dealing with player choice. If you play Dragon Age II, this becomes apparent."

I've played ME2 and ME3, which makes it apparently to me that they don't have any problems when it comes to player choice.