User blog comment:StagedDom19/Missing the Main Problem/@comment-5008642-20120712005513/@comment-24174486-20120713062949

Factually inaccurate arguments:
 * "Killing the Rachni Queen, consequences? None." If you kill the rachni queen and save the fake queen, the queen goes on a frenzy, causing you to not only lose the rachni War Asset but also suffer a deduction from another War Asset.
 * "and no one seems to care that you said you didn't want the genophage cured..." Having told Mordin to destroy the genophage cure data is one of the factors that determines if you can convince Mordin/Padok Wiks to fake the genophage cure.  (The other is Wreav leading the krogan.)
 * "destroying the Collector base is pointless" Your decision for the Collector Base lowers either the EMS requirements for the Destroy (destroying the Base) or Control (keeping the Base) endings, as well as determining which ending you get if you have the lowest EMS bracket (less than 1750).
 * "the endings are all pretty much the same" The endings vary by the fate of galatic life, the fate of the Reapers, how much damage is caused by the Crucible's activation, and if your squadmates and Normandy crew survive.  Of course, there's still everything else you've done—or does the result of the geth/quarian conflict, the rachni, etc. suddenly become invalidated by which option you chose?

You also ignore that the "replacements", as you consider them, are significantly different characters. Wreav is an especially prominent case, as his goals for the krogan are much different than Wrex's and will result in a much different outcome in the end if the genophage is cured. As you also point out, Wreav can be fooled into thinking that the genophage was cured. Wrex cannot, and sabotaging the cure will cost you the krogan War Assets.

There's arguments that are made because a person doesn't have any reason to believe otherwise. Those are understandable. And then there's arguments where anyone familiar with the work will immediately shake their head and scoff. Where you don't make claims that are provably false, you sidestep around the consequences of your choices and, ironically, focus on scenarios that only occur based on the choices you've made.

Of course, this isn't the only poorly-researched rant about the series. It's a little depressing that I expect factual inaccuracies any time I see someone complaining about the ending... and even more depressing that the majority of the time that I'm wrong about that is when they don't provide any evidence for their arguments.