User blog comment:Leviathan2186/Mass Effect 4: Wish List/@comment-1786741-20130716154356/@comment-1786741-20130717061804

Well, the whole "everyone is part synthetic" thing isn't something that could be easily implemented. First off, they have to add that green glowing effect to EVERYONE. Second, they have to acknowledge it other then saying "Oh, by the way, everyone is part synthetic now". Something like that would alter the world drastically. Hell, just look at the ME sequels we already got. Relatively, the plot stayed the same save for the occasional cameo and such. In comparison, those choices were much smaller than the universe spanning ones in ME3.