User blog comment:James12708/Possibility of a Mass Effect 4/@comment-5484632-20130430172854/@comment-8419211-20130430175805

Well, we mentioned it in some of the previous posts. Destroy ending should be canonical. 1. Shepard is a hero and most of heroes usually survives in the end. Only destroy option gave to us this opportunity. 2. BioWare stated that next ME game will be different from the trilogy. Reapers survived in 3 endings - Synthesis, Control and Refusal. Only Destroy option will give us this difference. 3. Synthesis - utopia. It's impossible. No conflicts, no wars. 4. Refusal - in that case next ME game will be about "how to defeat the reapers". Some one will find Liara's box ( or what was it) where she explains how to defeat them using crucible, blueprints of crucible included. 5. Control - another Reaper created with shepard's memory. They will be more powerful. All civilizations will live under pressure cuz the reapers are still exist and no guarantee that reapers have no plans about harvesting all organics. cuz we can't comprehend them.

so basically, BioWare statement about another ME game which will be different with the trilogy, give us another hint - that next ME game could be about future events, no past. cuz if it will be about past events - reapers again. And we all know how previous cycles ended.

hope it helps you