User blog comment:Aleksandr the Great/Bioware HAS Written Themselves into a Corner/@comment-5287758-20121110094841/@comment-4950455-20121110104703

I don't understand why people think that setting a sequel far in the future would make up for any of the different possibilities. What, just because it's 500 years later, we can ignore everyone being part-robot? And that's the one that has the most chance of coming to pass "naturally". It might help deal with the questions of individual characters, but it doesn't solve the main problem.

Personally, my gut feeling as to the best way to make a post-ME3 game would be to not use any of the endings exactly, instead declaring the game an alternate continuity (or something similar) where the Reaper War ended in a different way altogether, most likely with the "status quo ending" many ending-haters still keep dreaming of. The decisions your Shepard made would not be overriden, and the greater Mass Effect saga would be able to continue on.

There's a ton of problems with this idea, and I'm not sure it's the best. But if the series must continue chronologically past ME3 - a decision I'm not in favor of - this is the way that I keep coming back to for doing it.