User blog comment:Ramallah/Mass Effect 3 details revealed/@comment-1886172-20110410182257/@comment-1726879-20110414093421

Probably so. If he has the collector tech, he may think that he no longer needs Shepard, and so he's just getting rid of a loose end. If he doesn't then he may think that Shepard is a danger to the survival of humanity and he must he eliminated. Only Bioware knows right now.