User blog comment:The Milkman/Extended Expectations, Part II/@comment-4939034-20120628162252/@comment-4237253-20120628214722

@Commdor Perhaps, but considering Mass Effect is more focused on story and player choice than any of those games, I'd say there's no real way to make a sequel without invalidating other endings and destroying the purpose of player choice.

@Johncmousley Whilst I did choose Destroy because I believed we needed the Reapers dead, Synthesis is probably the only choice that doesn't result in the same mistakes being made.

@GodzillaMaster Yes, but that was one outcome, and it wasn't a very common one. You have to be trying if you lose almost your entire squad. This would mean failing to do any side missions, not buying any upgrades, and making all the "wrong" decisions in the final mission. However, Shepard dying in the end of Mass Effect 2 isn't the result of one pivotal choice. Rather, it's the result of negligence, laziness, and several bad choices. The worst endings to ME2 were varied, but not too far-reaching. With ME3, any possible sequel would be unable to take into account differences that big throughout the game.