User blog comment:The Milkman/How Do You Play?/@comment-2228120-20120616053319/@comment-1388547-20120616145034

I generally take all the interrupts on my first playthrough, but scale it back to mostly ones appropriate to my character's morality on subsequent times through the game. All my Paragon characters (except the first) nobly refrain from pushing the merc through the glass, and all my Renegade characters do it because it's too tempting to pass up.

As for dialogue options, I mostly take the ones that go with my current morality, but there are a few where one direction or the other just strains credibility. Particularly the ones after the Collector Ship mission -- the Illusive Man always gets an earful of Renegade after that, and there's no way I'm defending his actions to my crew.