User blog comment:LilyheartsLightning/Citadel and Reckoning DLC announced/@comment-4782844-20130223190909/@comment-4782844-20130223211304

Well if the majority are dead, maybe this means whatever mission you're on will suffer. E.g if Miranda's dead it's much more harder to save Oriana at the sanctuary So if Wrex, Mordin and their replacements are dead then, maybe things will be much more harder? (and less interesting)

And i doubt people will want to interact with Jacob, apart from punching him for being a cheating S.O.B