User blog comment:James12708/Possibility of a Mass Effect 4/@comment-203.206.104.157-20130215120020

How about mass effect 4 maybe 4 - 10 years later after the relays have been rebuilt. And everyone is joining together, with the occasional minor conflicts. Choices can be uploaded from previous games. If you cured the genophage then the krogan gave flourished throughout the krogan dmz. If it was sabotaged then maybe their are only very few sickly krogan on tuchanka under quarantine from salarians. The dalatrass could be in prison. If kirrahe lived then maybe he's an admiral.

The ending of me3 may not have been perfect but it could make more of a difference in no. 4 where the reapers sacrifice themselves to destroy the primary antagonists (control), they assault and destroy the antagonists and survive (synthesis), or the antagonists come and kill millions, even some you know (destroy).

Characters from your squad who survived can make cameo appearances and have dramatically changed since shepards death/disappearance. Also, as much as I believed the indoctrination theory...and I still do...if they make an me4 that makes up for me3's ending...then we're cool