User blog comment:James12708/Reapers VS. Forerunners VS. Angels from Darksiders VS. Humanity from Halo VS. Council and humanity from Mass Effect VS. Imperium of Man/@comment-50.80.96.33-20130124014617/@comment-1786741-20130124041036

I'm somewhat in agreement with this. The Flood are only really as effective as the race they infect. Considering the Reapers aren't really organic (yes, they're made with organic materials but are for all intents and purposes synthetics made from organics) the Flood will have a hell of a time trying to infect them. Then again, considering the Flood probably can't infect them I'm not sure what their interest would be in the Reapers anyway. Since the Flood wouldn't ever create synthetics, it might be actually kind of beneficial towards them.