User blog comment:J Shepard/Joker/@comment-217683-20100127200620

Yeah, I'd have to say his disease likely rules out the possibility of a romance with him. They can't really afford to be too subtle with Romance in the game. There has to be a moment where you know for sure that this romance option is "The One", that it's locked in and will be the one that counts, as opposed to the other possible options, and that moment comes when Shepard and the romance option consummate the relationship, and Joker can't really do that, can he? Poor guy.