User blog comment:BossDarkseid/Question regarding ME2 DLC and ME3 save importing/@comment-774818-20120201032152

While you only need one blog post to ask your question, my guess is "No." Save files recognize if DLC is installed or not. If you try to load up an ME2 file that has DLC played, and that DLC is not installed, it'll say "You're missing the following DLC:", and won't load up the game.

I don't see why ME3 would be unplayable if ME2 DLC is not installed.