User blog comment:N7EagleEye/New Mass Effect 4 Details/@comment-5472420-20121020060841/@comment-1153722-20121020125021

I don't think creating new species would be a big problem, considering that this game will be a fresh start. If they put the next game in a different cycle, it certainly would not have to be about the Reapers. I'm sure the species in other cycles had a lot of interaction and conflict between each other as well. Of course, it would lose the human element that a lot of people easily relate with and that all previous three games have focused on, but with good writing they can easily get around that.