User blog comment:Chaoswolf75/What's the hardest choice you've had to made throughout the series?/@comment-5212406-20120717023759

ME1: Allowing the council to live or die, the fate of the Rachni Queen, and rescuing the hostages or capturing balak in BDTS.

ME2: Keeping/Destroying Maelons data, saving the workers at the refinery or gain zaeeds loyalty, rewriting/destroying geth heretics, deciding if i want to keep facial scarring

ME3: deciding if i still want to keep facial scarring, sabotage/cure genophage, saving rachni queen or aralakh company, letting thane defend councilor, making peace between geth/quarians, romancing Miranda or Ashley, choosing control/synthesis/destroy.