User blog comment:Chaoswolf75/What's the hardest choice you've had to made throughout the series?/@comment-1907847-20120712120406

Mass effect 1: Without any shadow of a doubt, sacrificing either ashley or Kaidan (Kaidan in my case) Mass Effect 2: Evidence in the trail of Tali'Zorah (My romance at the time) Mass Effect 3: Rachni Queen.

And as a Bonus my ACCIDENTAL choice in ME3: Romancing Liara by mistake, I still wanted to pursue Tali Zorah.