User blog comment:ExSturminator01/Mass Effect 3 Predictions based on ME2 hints/@comment-1829604-20100215154739

My speculation about how to defeat the Reapers: send over EDI and have her disable them all at once, perhaps with a loyalty twist of hers (e.g. defeat vs take their place). Sending a simple virus (aka Independence Day) would be too simple. Eliminating large packs of reaper ships might be possible with a supernova - see Haestrom's potential. Assembling a fleet might be a good idea to buy time for uploading EDI in a final battle. I imagine a plot where there is an ancient reaper who you could find and have it join on your side (similar to Babylon 5's First Ones). (It would tell you about their program for perfection but some renegades choose to do it violently by outsourcing evolution and harvesting the results.)