User blog comment:Tiredman2/What is your favorite moment in the Mass Effect trilogy?/@comment-5379655-20120824051246

For me, it's:

1) The leaving Earth cutscene when the boy is killed. Most emotional impact for me in the whole trilogy.

2) Virmire: leaving either Kaiden or Ashley to die.

3) The Lair of the Shadow Broker. Pretty much the entire DLC was fantastic.

4) The destruction of the Normandy in ME2

5) The fall of Thessia and Shepard's failure had a pretty big impact on me as well.

But the leaving Earth cutscene was by far my favorite