User blog comment:The Milkman/The Next Effect/@comment-86.111.88.50-20121127130800/@comment-86.111.88.50-20121127135802

It depends on your definition of sequel, mate. I see it as a new storyline in a known setting, you see it more like a continuation of Shepard's adventures. The latter isn't going to happen, unfortunately, and on the other hand - we still have a whole galaxy ready to produce stories, even if the cycle was not broken in the end of ME3.