User blog comment:James12708/Possibility of a Mass Effect 4/@comment-5687135-20121031201025/@comment-1786741-20121101215409

Yeah.... this idea doesn't really work due to some major pitfalls. First of all, if you choose Refusal the current cycle is killed off. It's not a point of debate, everyone is dead and the next cycle eventually defeats the Reapers. Second, if you choose Synthesis everyone is partly synthetic down to their DNA. Everyone understands each other or something, I never really got that part, and there's galactic peace. This whole "But they could react to be synthetic or something and attempt to get rid of the synthetic parts or start causing conflict" is mass speculation and sounds highly convoluted.