User blog comment:AdmMiller/BIOWARE, YOU HAVE BETRAYED US!!!!!!!/@comment-204.210.207.90-20100915190317/@comment-743796-20110315231859

With the last sentence, it's stated in Miranda's Dossier file that the neoplasm damage caused by her creation (or something else) destroys her ability to have kids, but it could also mean her DNA is "locked" meaning even with in-vitro fertilization, the process will fail.