User blog comment:Garhdo/Mass Effect: Andromeda/@comment-1440333-20150618231547

One query I have, what with the fact we were told it might be an idea to hold on to our saves, is exactly how much of an effect our past decisions could have on this game. After all most characters we encounter can possibly die as a result of Shepard's actions (Hackett is one of only a few notable exceptions), presumably the characters of this game will have left the Milky Way prior to the Catalyst firing (to avoid any more ME3 ending controversy), and most quests from the original Trilogy were resolved in some form as part of the War Asset system, and were therefore used in the battle for Earth.

So what is there left that could play a role?