User blog comment:Agentsmit58/Shepard's story has truly ended and wont have DLC to continue the story!!!/@comment-2127388-20120528074845/@comment-4950455-20120528193338

@Thewarrior2012: The problem is, even if they find a way to work around that, it brings in an entirely different issue: that of undercutting player choice.

For instance, say that Bioware decides that this hypothetical post-ME3 game will feature a revitalized krogan empire, and so has the krogan manage to find a cure for the genophage on their own a few centuries down the line. That would mean that the player's choice during ME3 - the climax of perhaps the best story arc in the game, to boot - was ultimately meaningless. Players who destroyed the cure might have delayed the return of the krogan by a few centuries; players who preserved it might have sped things up, but ultimately it didn't really matter in the end.

@Traditionalfire: No, just three - geth, quarians, and rachni. The other races may be hurt, but they'll survive ME3 no matter what you do.

Well, I guess the Reapers' survival also depends on what you do, but I doubt they'll be heard from again even in the endings where they survive.