User blog comment:James12708/Possibility of a Mass Effect 4/@comment-5687135-20121031201025/@comment-49.176.97.25-20130107050027

I think it's pretty obvious that if you choose refuse, you don't win. Bioware did a simlar thing in ME2 with Shepard's possible death at the end. However, apart from that, this is by far the best suggestion I've seen. It could also add in the Krogans reaction to the resolution of the genophage. Whether they restart the Krogan rebellions or get caught in a massive scale civil war due to Wrex/Eve's ideas on how they should progress.