User blog comment:James12708/Possibility of a Mass Effect 4/@comment-5677633-20130308194849

I think a good idea is to have the next game set on Omega and you are a member of one of the mercenary groups fighting for control. You could be a young squad leader and keep the role playing elements by outfitting yourself and you squad with abilities, armor, and weapons as you progress. The timeframe would have to be before Mass Effect 3 when Cerberus took over though. With this setting you can play as different species, have co-op or competitive multiplayer, and not have to worry about having an antagonist more feared than the Reapers. None of your choices would ultimately affect the outcome of the overall Mass Effect story so keeping continuity wouldn't be a problem either.