User blog comment:Bluegear93/Old, Unhappy, Far-Off Things/@comment-730941-20101118152740

Not that I'm aware of; although we can't rule out any consequences for ME3. I'm unsure if the brief mention of Shepard's mother in ME2 is tied to the Spacer background or having completed the mission; I'd tend to think it was the former. Summing up, I don't think it affects ME2 but it might play a tiny role in ME3 (we honestly have no idea yet).