User blog comment:Stabber ApSig/Mass Relays Gone, ME3 ending/@comment-3097746-20120312053137

From the Mass Effect 3 article, section "Plot"

"The story is the 'epic conclusion' to the story started in Mass Effect and continued in Mass Effect 2, as well as the conclusion of Commander Shepard's story."

Now we highlight a part of that

"the conclusion of Commander Shepard's story."

We won't see then end of the Mass Effect story. There are sure to be other forms of media, possibly new games, that will continue the Mass Effect story with new protagonists. That's how Bioware did KOTOR