User blog comment:Nord Ronnoc/Details of new Mass Effect game from private PAX presentation/@comment-5521671-20131126010928

Andromeda is 2.538.000 light-years away from Earth. I don't think the next ME is going to take place in another galaxy.

I think it's more likely we are going to explore a unknown part of the galaxy.

If I remember right the ME3 codex states less than 1% of the Milky Way's stars were explored by the council races.