User blog comment:Lancer1289/Mass Effect will go on, but without Shepard/@comment-2127131-20110831132736/@comment-743796-20110831133921

Well, they're doing something similar with Assassin's Creed: Revelations, where the creator stated it will be the last time we see Ezio and Altair (and maybe even Desmond, but I'm not sure about that).