User blog comment:Kaloneous/Mass Effect 3 Ending DLC Denied and PAX/@comment-4916217-20120316175100/@comment-1388547-20120316210349

I would argue that, regardless of work on improvements to ME3, it's very unlikely we'll see another game that comes after it in the Mass Effect series -- at least, not unless BioWare has a lot of non-player-controlled events that help prune the branches of the story. Consider: by the end of ME3, the genophage may or may not have been cured; if the genophage was cured, the krogan may have enlightened leaders (Wrex and Eve) who see the value of peace with the rest of the galaxy, or they might be on a trajectory toward a new round of Krogan Rebellions; the quarians or the geth may have been wiped out, or they might be living together in harmony; the geth may or may not be upgraded with Reaper code. That's a pretty tangled snarl of possibilities, and it would be too much effort on BioWare's part to make a game that can cover all of them, especially since any individual player probably won't see most of them.

I expect there to be more games in the Mass Effect franchise, but I expect them to be side stories (like Mass Effect Galaxy) or prequels. The First Contact War would be a prime candidate, or maybe some fun with the various races' spec ops teams -- games based around an STG or asari commando unit.