User blog comment:LoneGrenadeWolf/How to Regain Loyalty/@comment-737801-20110102031654

You can regain loyalty by talking to them, which requires even higher paragon and renegade points than the initial confrontation. It is recommended you hold off on those confrontations until the end if possible. Your second is a good benchmark for the first. See Miranda: The Prodigal or Jack: Subject Zero for more.

Hope this helps.