User blog comment:MEffect Fan/Truth.../@comment-2088100-20100601054604

Well, that would be a prequel to ME3, not ME2 :D If you're concerned with how they'd deal with decisions made in that DLC for people that don't have it... I'd assume they do what they do for people that don't have ME when they start a ME2 game: Apply certain "canon" states, then send em off.