User blog comment:James12708/Possibility of a Mass Effect 4/@comment-5267262-20120728114735

just remember that anything set after mass 3 would have to either be able to import mass 3 and have a plot that could still run no matter which use of the cruicible (or not at all) was made along with choices like saving the geth/quarians (assuming you don't get them all wiped out by the reapers from not using the crucible). I think it would be safe to say that IF there ever is a mass 4 cronologically after mass 3, the milky way would not be the setting. IMHO it would be running parallel to any of the first 3 games.