User blog comment:Arbington/ME3 Theories/@comment-899316-20100703004352

Previous characters both can and likely will play major parts in ME3. Take Kaidan or Ashley for exemple: either of them can die, but it is generally accepted that they will play a major part in the next game. Also, if Wrex survives to lead Clan Urdnot, they have an almost entirely different stance on almost every Krogan issue than if Wreave is the leader. Does it effect gameplay? No. But it sets a whole new stage for the Krogan in ME3.