User blog comment:James12708/Bioware Hasn't written themselves into a corner/@comment-4950455-20121109062047/@comment-4950455-20121109074054

Other Space Cthulhu, perhaps? (Not a serious suggestion).

Actually, though, one of the things that was always most appealing to me about the Mass Effect universe was its scale. Given the scope of that universe, I don't know if the Reapers need to be "topped" at all to tell a different story, especially since Bioware seems to be wanting to do something a little different anyway.