User blog comment:James12708/Possibility of a Mass Effect 4/@comment-69.62.165.196-20121028063016/@comment-24174486-20121029022742

Victory through sacrifice is a major theme of ME3. With a high EMS, Shepard survives the Destroy ending, but synthetic life is still sacrificed. It would contradict the moral of the game if you were given a sacrifice-free solution.

(Besides, my theory on Destroy is that it targets synthetic systems, hence why it disables the partly-synthetic Reapers and all other synthetic life. And I like my theory. X3)