User blog comment:The Milkman/Mass Effect in Retrospect/@comment-24174486-20130418150425/@comment-24174486-20130418171138

Ah yes. The idea that the being that created the Reapers, that existed before the Reapers themselves existed, is a Reaper.

We have dismissed that claim.

Incidentially, I did provide evidence that does lend some weight to the Catalyst's viewpoint. The closest you came to a response to it was demonstrating that you don't get what "inevitable" means.

Also, synthetic/organic relations was also a theme in the series. And let's not forget the Reaper on Rannoch.

Shepard: "Organics and synthetics don't have to destroy each other!" Reaper: "The battle for Rannoch disproves your assertion. Finish your war. We will be waiting."

(Incidentially, while searching for the exact quote, I found this very interesting look at the dialogue with the Reaper on Rannoch.)