User blog comment:James12708/Possibility of a Mass Effect 4/@comment-69.62.165.196-20121028063016/@comment-3228423-20121028185941

Not unless they make three separate campaigns and the campaign you play would be a continuation of the final choice you make at the end as well as factor in all the decisions that you made throughout the trilogy. For example, you choose Destroy with a high EMS as well as cured Genophage with Wrex leading the krogan, the Noveria rachni queen spared both times, and peace between the quarians and the geth, then all synthetics would survive, and the geth, the krogan and the rachni are members of the galactic society in peace while you play as Shepard (or if the game would be set in the far future, a descendant of him/her if you romanced Ash, Liara, or Kaidon; a descendant of an adopted child if you romanced Tali, Garrus, Miranda or any of the others; or someone completely new) while the player would once again have to bring the galaxy together to fight off a new threat. This would probably be the harder campaign as you have no reaper buddies to help out. And so on for the other two.