User blog comment:Austin1395/Mass Effects Future/@comment-24174486-20130116004958

If anyone could make a sequel to the Mass Effect trilogy, it would be BioWare. Depending on how far into the future, a ME game set after the trilogy would only need to focus on the choices which would have the greatest future impact—what races survived, the final choices of each game, etc.

Personally though, I would want to see what BioWare wants to make. As I learned when they decided to add volus into multiplayer, even if BioWare does something that sounds incredibly stupid, it'll still turn out awesome. XD