User blog comment:Bronzey/Tying up the threads: possible storylines of Mass Effect 3/@comment-1763658-20100428193955

Bioware has said that ME3 will be last game that follows Shepard's story arc. They said that's its highly probable that there will be more ME games in the future.

P.S. Saying Shepard will die and have one, concrete ending is dimensional nonsense. I mean, seriously dude.