User blog comment:James12708/Possibility of a Mass Effect 4/@comment-86.159.85.114-20120919151324/@comment-5529312-20120922031825

The only way for Shepard to have any kids is if Male Shepard romanced Liara or Ashley or Jack. Only Femsheps will be able to have kids with Liara. Too much limitation.

This idea is not an option. Bioware really got themselves into a tight mess after ME 3.

I agree it shouldn't end with ME 3, but they already killed shepard in ME 2 and brought him/her back to life. They don't get to do something like that again.

Likely only 2 possibilities exist for a sequel:

-Destroy: After Commander Shepard fired the Crucible and destroyed all synthetics a new hero must now rise up stabilize the galaxy. (Depending on which of the destroy endings, the game should be adapted to that.)

-Defy the Catalyst: The Cycle Continues but thanks to Glyph, the next cycle will be prepared for them. (There would be Yaghs and other new species to play.)

Synthesis and Control offer complete peace and there seem to be no interesting capabilities attached.

The capabilities for a Prequel are far more numerous and so forth but the endings would all have to be fixed and that might ruin the rpg element of it, and it would be less epic as compared to the Reapers, which might promote story instead which is good. Either way a new game was already announced, so fingers crossed!