User blog comment:The Milkman/Indoctrination Theorists Say the Darndest Things, Part II/@comment-5830255-20121205095424/@comment-4237253-20121205210455

I'll name a few meaningful choices.

1. You have to choose to save Kaiden or Ashley on Virmire. 2. You can commit genocide four times. 3. Whether or not you solve your squad's daddy issues can result in the deaths of more than half a dozen people. 4. Did I already mention that you can bring four sapient species to extinction!?