User blog comment:Raymorn/Bioware Co-Founder Dr. Ray Muzyka Speaks Out/@comment-2094653-20120322005556/@comment-5503561-20120322022404

Plus if we go by AngryJoe's explanation, in the Destroy option, Shepard does break Harbinger's hold on him. Notice how he stops limping and gets a second wind when he walks and fires at the machinery.

So yeah, Shep can do it.