User blog comment:StagedDom19/Missing the Main Problem/@comment-4085370-20120710054824/@comment-5274392-20120710145124

If you are paragon and you killed the Queen in ME1, only to save her in ME3, she will be unable to work with the Alliance and go on a rampage. Wreav being the leader of the Krogan and actually curing the genophage is supposed to be a bad way to deal with the Krogan.