User blog comment:James12708/Reapers VS. Forerunners VS. Angels from Darksiders VS. Humanity from Halo VS. Council and humanity from Mass Effect VS. Imperium of Man/@comment-50.80.96.33-20130124014617/@comment-4967682-20130124034227

Not really; the Flood are essentially as strong as they need to be to wipe out an organic species, since they use their technology. They ever tried that on the Reapers they'd get stomped, because A. Reapers can't get infected and B. the tech they could take from the organics of the Mass Effect universe can barley scratch the Reapers.