User blog comment:James12708/Possibility of a Mass Effect 4/@comment-1440333-20130225143536/@comment-1679409-20130225181944

The problem BioWare is going to have is they're damned either way. If it's a prequel that deals with something like the First Contact War, the Metacon War, the Prothean-Reaper War, the Morning War, the Krogan Rebellions, or the Rachni War, then they have the issue you bring up: We know how it ends. That takes away a lot of interest.

On the other hand, if it's a sequel, then 1) how do they take into account all the variables including the possible extinction of entire species (quarians, geth, Reapers, rachni) and 2) how do they top the Reapers?