User blog comment:Nord Ronnoc/Details of new Mass Effect game from private PAX presentation/@comment-5521671-20131126010928/@comment-1679409-20131126011711

Who's to say there isn't a mass relay that connects the galaxies, such as the relay the Reapers use to go from Dark Space to the Citadel? It could also involve one of the smaller companions of the Milky Way instead.