User blog comment:Lancer1289/Mass Effect will go on, but without Shepard/@comment-68.36.73.206-20110901000654/@comment-86.178.230.248-20120906201516

Well what I can think of at the top of my head is an energy based entity that threatens not just life but physical existence as well (i.e. plans to cause a "Big Crunch" or some such). Might not happen that way of course