User blog comment:Masseffect7/Mass Effect 4 - No Connection to Shepard/@comment-1786741-20131020213539/@comment-5521671-20131029224511

The new ME: Foundation issue(#4) implies both Kaidan and Ashley were alive after ME1(unless it was a huge mistake), so maybe they will mix things from diferent endings to make a canonical sequence.

My bet would be Reapers dead(Destroy) + every species alive(Control)