User blog comment:Arbington/New ME4 Teaser Pics, Possible Upcoming Reveal/@comment-1440333-20131112224244/@comment-1679409-20131113003232

I wouldn't be so sure about humans being in the next game. We don't know for sure if it's going to be a prequel, a midquel, or a sequel. A prequel or a sequel could theoretically take place during other cycles, ones in which humans haven't evolved yet or have gone extinct.

I actually kind of want to see a story that is from a different cycle. Or, it would be cool to see a story that spans multiple cycles.