User blog comment:AdmMiller/Who's pschyed up for ME3? (Romance options only)/@comment-730941-20100712032938

Apparently most mods that enable same-gender romances just modify the gender-check for romance options (i.e. the game would 'see' you as a male for the purposes of romancing Miranda, but female in every other respect). I've seen Kaidan-MaleShep romances in the original Mass Effect imported into ME2 with no problems using this method. So it looks likely that it would work OK, but of course it's hard to tell - it's possible that modding the game in this way could result in weird things happening in ME3 (I've seen some mods in the first game where the player's Shepard either had no face, or abruptly morphed into the other gender in the middle of a cutscene...).