User blog comment:Agentsmit58/Shepard's story has truly ended and wont have DLC to continue the story!!!/@comment-2127388-20120528074845/@comment-4826433-20120528183810

A new game without Shep will definitely not be the same, but it will open up new frontiers for gaming. Maybe they can make a RPG-RTS combination like Starcraft or something more innovative.

Shep was just one man/woman. It would be interesting to see the galaxy from the view of the many unsung and faceless ones out there.

As for villains, Bioware can work something out, cant think of any plausible story for setting new enemies. Maybe the beings of light or whoever built the Reapers will have some role to play.