User blog comment:James12708/Possibility of a Mass Effect 4/@comment-166.205.55.44-20130401145224

A good setting of Mass Effect 4 would still be in the same galaxy. But it would be 100 years or so after Reapers and Shepard. The conflict could be a kind of First Contact War with a species that traveled from a whole new galaxy with new technology. The new hero would be tricky. Maybe a relative of Shepard; not his children, but it never told us in the series if his parents had brothers or sisters that had children or not. Or a whole new character. New classes and all that fun stuff.

This would be quite amazing.