User blog comment:Agentsmit58/Shepard's story has truly ended and wont have DLC to continue the story!!!/@comment-2127388-20120528074845/@comment-4950455-20120528185259

The problem with a post-ME3 game isn't really Shepard or their crew. It's all of the other possible differences.

People tend to view all of the endings as the same, because there's no on-screen difference except for the color of the explosion, and because the bad elements common to all three tend to outweigh those differences. But from an in-universe perspective, all three are considerably different.

And even without taking the endings into account, there's lots of other possible divergences. Either the geth or the quarians might be extinct, or both could have made peace. The genophage may or may not be cured. The rachni may or may not have returned.

I'm sure there are ways some of these could be worked around, as with the artificial rachni queen from ME3, but nonetheless, I feel like there's too many potential differences to reconcile for a post-ME3 game to be feasible.