User blog comment:Tali's no.1 fan/Most Hated Enemy Of Mass Effect/@comment-1388547-20110514220347/@comment-255294-20110520231340

Thresher maws have a limited number number of locations where they can emerge. When it first pops up. Get somewhat close to it (maybe 10 Mako-lengths), and circle strafe back and forth to avoid the acid spit. Stay within a small area until it pops up in a new location. Thresher maws will always pick locations that are close to Shepard, so you can limit them to 3 or 4 spots.