User blog comment:N7EagleEye/New Mass Effect 4 Details/@comment-5472420-20121020060841

The story can't be completely different from ME1-3 if the game's going to be a sequel. If the game is a prequel, then there are a lot of options for ME4, like the First Contact War, or even when the Protheans were still alive, who knows. I'm just hoping they bring back, or at least mention, characters in the first three games if it is a sequel.