User blog comment:Stealth Cl0wn/The deaths that hit you the hardest (Massive spoilers)/@comment-3538356-20120416194739

Mordin sacrificing himself to cure the Genophage.

Thane giving his life to save the Salarian Councilor.

Legion sacrificing himself to give all geth intelligence.

Tali committing suicide.

Miranda dying if you didn't talk Henry Lawson down or didn't warn her about Kai Leng.

Anderson dying.

Shepard sacrificing themselves to end the Reaper invasion.