User blog comment:Bioshocknall/Shepard kids pt 1/@comment-217683-20100505082255

I would say yes and no. Yes, it would be possible for Shepard to have a child with an alien. Were you to romance Liara, she could bear Shepard's child, regardless of whether Shepard is male or female. Would that child be a 'hybrid'? That one is open to some interpretation.

If you mean hybrid as in a genetic mix, then no, it wouldn't be a hybrid child, as children born of an asari and a non-asari are always asari. However, new information from ME2 does seem to indicate that something of the 'father' (as the asari, being the one who becomes pregnant, carries to term, and gives birth, is the 'mother') is carried over, including some aspects of the father's race, at least inasmuch as racial characteristics and inherent instincts are concerned. In that respect, yes, the child could be considered a hybrid.

So, in answer to the question, yes, it would be possible for Shepard to father a hybrid child... sort of.