User blog comment:Garrusvakarien/Do you think there will be another mass effect?/@comment-294719-20130312203942

BioWare has already begun development on it. They say it'll probably hit sometime next year, and that it's going to use the Frostbite 2 engine, though they're still not sure if it would be a proper Mass Effect 4, a story that runs parallel to Shepard's, or even a prequel to the first trilogy. But yes, there will be another Mass Effect game.