User blog comment:SoulRipper/Non-Standard Weapons that you can or can't miss in a Mass Effect 2 playthrough./@comment-1894157-20100821013726/@comment-3006493-20100821080945

"which can only be unlocked on Haestrom if played on hardcore or insanity" Thats not what I mean about missing a weapon. For example the M-27 Scimitar. Whatever you do you can't miss that weapon. Even if you don't take it from any of the 3 places that you can find that shotgun, the game will give it to you as an award at the end of the mission (see M-27 Scimitar talk page). If you don't take a weapon when you can and you don't obtain it at the end of the mission as an award, then we can say that, that weapon can be missed.