User blog comment:Arbington/The Next Cycle/@comment-5267262-20120803203730/@comment-1221773-20120803222308

That was a Hades Cannon that Shepard destroyed with the Cain. They may be less resilient than a true Destroyer (consider how many orbital strikes it took to disable the Destroyer on Rannoch. It wasn't even totally destroyed).

And there is a space battle cinematic where a Destroyer lands on a turian cruiser and rips it apart with its laser. I'm sure the laser would be just as effective at longer ranges than point blank.