User blog comment:N7EagleEye/New Mass Effect 4 Details/@comment-98.114.32.146-20130622051124/@comment-1679409-20130622104733

I'm going to assume they're not going to go that route for several reasons:

1. What about female Shepard's? Any baby they're carrying would have gone out with them.

2. Most romance options would not lead to pregnancy for Shepard or the partner for biological reasons. The homosexual romance options would obviously be one case. Another case would be most alien romances (other than Liara) as those pairings would probably be biologically incompatible due to differences in chromosomes (etc. Thane's a reptile, Garrus is avian) and/or differences in DNA (Garrus and Tali are dextros). So the only romances that could lead to pregnancy are the heterosexual human romances and Liara.

3. It's possible for Shepard's love interest to be dead by the end of Mass Effect 3, too.