User blog comment:James12708/Possibility of a Mass Effect 4/@comment-4237253-20120929213218

I've already written a blog on this, and I still feel that sequel would be impossible to do in this universe without undercutting, retconning, or nullifying player choice. BioWare had to resort to all three after just one game (Dragon Age 2), so I don't think they can handle the massive consequences of the entire trilogy.

Besides that, it's best to leave the universe where it is. It's best to build a universe around a single story arc and leave it. The longer a developer tries to Milk a franchise, the more likely they are to ruin it.