Stay with me here:
So, the reapers in the milky way proved many times over that life is predictable. Every cycle will inevitably develop true AI, and without intervention, every cycle will be overwhelmed by true AI, until they create a reaper-like agent to reset the cycle every 50,000 years.
Mass Effect's rules allow for one of only three possibilities in the Andromeda Galaxy:
Possibility #1: Andromeda is controlled by synthetics, who reign supreme and unchallenged
Possibility #2: Andromeda has it's own reapers who periodically cull all intelligent life
Possibility #3: Andromeda is in it's first ever cycle.