Wish I could let you know but I don't think so, mate. I believe it is Mass Effect's way of saying to Shepard "Don't stick dat dingle-ling in someone else, ya dig?" so sadly I don't think so but anything is possible, just be sure to interact with Miranda(after you break-up) as much as you can throughout the game whenever the opportunity arises. However, don't take what I'm saying to the extreme because I romanced Miranda once or twice in my playthroughs and I think I broke up with her once and it didn't go so well but maybe try what I've suggested and it may just work. Just try and make her be vigilant and on the look out for potential threats(sounds stupid but if you see a dialogue option that appears to be like this then chose it) so yeah, that would be my suggestion. Have an awesome playthrough, mate.