The Renegade resolution to Conrad's quest in ME2 and Shepard's anger towards their clone over their hamster.

Another one is Tali and Garrus conversation on the Citadel.

Garrus: Tell me again about your immune system.

Tali: I have a shotgun

Garrus: Maybe we Will talk later.

I love drunk Ashley.

Taking James to save admiral Koris and having him shut down the first aa gun, he just kicks it

I just had this happen to me on ME3 but i just found it pretty funny. Inside Shephard’s apt, everyone is gathered together talking about the data they discovered from Kahn and suddenly Glyph gets on the table about to show everyone what he discovers when Javik says “It appears the drone is preparing to rebel”. 😂

Enjoy your drinks ladies..

Tali getting drunk, both times

Cross between taking Javik to Sur’kesh and anytime Garrus starts bragging.

T H E B I O T I C G O D

The way he just gives his speech and Shepard flatly says "Chaaarge." never fails to crack me up.

^ Or when he just gets shoved flat on his face.