A bad game with a familiar face is just as bad, if not worse, than a bad game with new characters. Duke Nukem Forever would not have been a best seller if it started Baron Bakem or Ronny Roastem. For that matter, I do not believe I would have enjoyed Andromeda any more if the brave explorer leading the charge had instead been Shep.
So for me at least, cast has little to do with quality. A returning character could be as perfectly introduced or butchered as a new character could be. As long as the writing is solid and the gameplay is fun, I will have a good time. Well, probably. It could be great quality but intentionally presented tonally as a complete emotional downer.
Off the list of potential newbies? Turian medic with robot hand would be my pick. We see very few obvious cyborgs. Even though Shep with max upgrades is sitting alongside New Vegas’ Courier as protagonist vying for the title of more machine than man with all their respective upgrades and perks, it’s hardly visible. Evil Shep can develop a little bit of an evil Terminator face, but that feels more like a science fiction version of Fable’s morality augmenting appearance than cybernetics. Closest we see at scale are species who require certain tech built into their suits to share environments outside their survival tolerances. The only 2 characters I can think of who wear visible upgrades are Saren and Lang, 3 if you count TIM. Seeing cybernetics as either prosthetics or willingly taken upgrades feels like it would be more common. Post Reaper, the number of injured and maimed who might need prosthetics would be even higher.