Mass Effect Andromeda was two things - a major letdown and something that broke franchise lore heavily.
But since we are supposedly getting a sequel to Mass Effect 3, I cannot help but wonder if BioWare should reuse the Angara and the Kett from ME Andromeda, but with new context?
By making ME Andromeda non-canon, they can reuse the Kett as a Terminus system race of nomads that are upstarts in spacefaring and are a nuisance for most, making it rare for a Kett to be reasonable with alien races.
Meanwhile the Angara could be a new race that had discovered the Mass Relays just as the Reaper Invasion had begun and their people bore witness to the intergalactic war. Seeing all these species waging war as their introduction to the wider galaxy, they are more skittish and timid initially; wanting to avoid aliens for fear of aggression directed at them.
Just an idea I had.