I'm going through the Shepard trilogy, and when faced with three endings (I don't take reject into account), I chose the ending of Destruction. I'll explain why right now.
As for me, Destruction is the ending that clearly shows that for any victory in the war you have to pay a terrible price. After collecting all possible resources, information, and specialists, Shepard and his Normandy team, together with all the forces of the galaxy, recapture the Earth and the entire galaxy from the Reapers. Yes, all synthetics, EDI, the Geth will be destroyed. The Mass-Relay network will be shut down because of this semblance of an "EMP-pulse," but no one claimed that we would not be able to restore everything. Shepard's decision does not roll back progress to the "Stone Age". In the same cut scene, it was shown that the Citadel had been restored, plus the Matriarch Etita proposed the idea of creating their own relays. (of course, I doubt that they will use it as a relay. After all, even before the battle for the Citadel, no one could have known that she was capable of fulfilling this role). So, there is hope that the galaxy will find an alternative replacement for relays, it will be possible to restore both Geth and EDI. Well, the cherry on this cake is that Shepard can survive with a high readiness of the galaxy (this moment really confused me, because it's not clear how it works at all)
Control is the perfect ending for a renegade, because you can "sacrifice" only Shepard so that he reincarnates into the Reapers AI, thereby becoming the new protective force of the galaxy. On the one hand, neither synthetics nor organics will have to make sacrifices, and the relays will be restored by the Reapers. But on the other hand, there is no guarantee that the AI-Shepard will not come to the same decision as the Catalyst - the destruction of all organics to prevent wars and deaths. This is literally the logic of tyrants - mass murder for the sake of salvation. You can't entrust your life to machines that can destroy you if anything happens, the risk is too high. Subjugating the Reapers according to the precepts of the Ghost will not be the solution to the problem, as Javik said.
Synthesis is a very strange ending. Crucible's EMP-Pulse generated "synthetic genes" based on Shepard's DNA, which were built to match the code of all living beings in the galaxy. It sounds quite strange and mystical. I understand that many people will say, "You're surprised by this, but you're not surprised by the mass effect, biotics, geths, and all that crap related to Reapers, Collectors, etc.", but at least it sounds more or less reasonable from the point of view of science (no matter how strange it sounds), in unlike the "sphere of energy", that irradiating organic matter adds "boards all over the body" to them + it is unclear how the body with new capabilities will function, too, is not displaced. The most ideal synthesis is Shepard HIMSELF, and as it is, this ending leaves too many questions behind. Yes, she is the ideal of what Saren wanted to achieve, but she, like Control, "deprives the feeling of price" in this war, which at least logically deprives that feeling of victory, so to speak.
I hope you were interested in reading this opinion. I must say right away - it is subjective. Write down what you think about this