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Liselle is a daughter of Aria T'Loak and the lover of Paul Grayson. Once Grayson started working for Aria (under the alias Paul Johnson), Aria had doubts about him and ordered Liselle to kill him, as she could find no information on his past. Instead Liselle pleaded with Aria not to have him killed, as Grayson was a useful and loyal subordinate.

Liselle eventually became Grayson's lover. One night after a job, they were attacked by Grayson's former employers, Cerberus. Despite Paul and Liselle's best efforts against the intruders, she was hit with a tranquiliser dart and knocked unconscious. Soon thereafter, Kai Leng killed Liselle by slitting her throat with a kitchen knife, leaving her to bleed out on Grayson's bed where she was later found by Aria.

The injury from the dart was small enough to be overlooked against Liselle's neck injury, leading Aria to suspect Grayson had killed her. Aria's fury at the loss of her daughter drove her to seek revenge.

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