After the development of mass effect FTL drive, distant Uranus was the target of a "land rush" to exploit its combination of plentiful helium-3 fuel and shallow (for a gas giant) gravity well. Today Uranus is the largest producer of He-3 in Alliance space.
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- The in-game information for Mass Effect incorrectly gives the orbital period of Uranus as 121.1 years; it is actually 84.3 years. This is corrected in Mass Effect 2.
- Sakharov Station is likely named for noted Soviet nuclear physicist and political dissident Andrei Sakharov, a key figure in the Soviet Union's nuclear weapons program who, later in life, specialized in cosmology.
- In Mass Effect 2, when the player sends the first probe to the planet, EDI comments "Really, Commander?", and after the second launch, she sighs "Probing Uranus…" This is a reference to a schoolboy pun: "Uranus" bears a resemblance to the English phrase "your anus". This pun has been literally translated in non-English versions of Mass Effect 2, but the comical effect is, of course, lost. At subsequent probe launches, EDI reverts back to her standard feedback: "Launching probe." or "Probe away."